Here are some tips, coming directly from the design team :

- Use all your Care items
- Make sure you collect as many Care items as you can every day, and use them daily.
- Use the preview tooltip often!
- Press and hold Care buttons to see a preview of your rewards. Use it to check which combination of care and creature will give the most DNA or Sanctuary Points!
- Level up your Sanctuaries as much as possible
- Use powerful creatures (high level and high rarity) to gain more Sanctuary Points and level up faster!
- Join an Alliance!
- This is probably the best tip we can give! An Alliance allows you to cooperate to level up your Sanctuaries as much as possible before they reset.
- Ask your allies to place the creatures you need in Sanctuaries you can access.
- This is a great way to get specific DNA of creatures you can’t find otherwise.
- Check with other players
- Maybe they have another great strategy that we didn’t even think about!